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Treat schizophrenia with 1 dose every 3 months with INVEGA TRINZA®.

When I was diagnosed, I was unsure what my treatment would look like. But luckily, now that I’m on INVEGA TRINZA®, I found the right treatment option that works for me and I’m living a pretty normal life at this point.

– A schizophrenia community member

How to Start Treatment With INVEGA TRINZA®

INVEGA TRINZA® is different from INVEGA SUSTENNA® and INVEGA HAFYERA® in that it's an injection given every 3 months. Your healthcare professional will start treatment for your schizophrenia with INVEGA SUSTENNA®, the once­-monthly version of the active medication in INVEGA TRINZA®.

After you have been adequately treated with INVEGA SUSTENNA® for at least 4 months, you and your healthcare professional can discuss whether a shift to receiving INVEGA TRINZA® every 3 months is appropriate for you.

It's important to be patient, because starting any new medication can be challenging. Work with your healthcare professional to find the right dose of INVEGA TRINZA® that will help control schizophrenia symptoms with the fewest side effects. It's very important that you go to all of your injection appointments. If you miss an injection, talk to your treatment team as soon as possible. If you are experiencing symptoms or side effects, be sure to let your healthcare professional know. You and your treatment team members can also discuss options to help remember your injection appointments, or if you might be able to receive your injection at a place near you other than your healthcare professional's office.

Clinical Trial Results


In a long-term study, 93% of patients taking INVEGA TRINZA® did not experience a significant return of schizophrenia symptoms vs 77% of those not treated.

The most common side effects of INVEGA TRINZA® include:

    • Injection site reactions
    • Weight gain
    • Headache
    • Upper respiratory tract infections
    • Feeling restlessness or difficulty sitting still
    • Slow movements
    • Tremors
    • Stiffness
    • Shuffling walk

After a 3-week screening period for medication tolerability, 506 people living with schizophrenia were all treated with 5 doses of INVEGA SUSTENNA® over 17 weeks. After that, patients whose symptoms were stable received 1 dose of INVEGA TRINZA® over 12 weeks. Then participants were randomly assigned to receive either an injection of INVEGA TRINZA® every 3 months or a placebo injection every 3 months.

  • What is considered an episode in the study?
  • For purposes of the study, an episode is defined as one or more of the following:

    • Hospitalization for schizophrenia symptoms (involuntary or voluntary)
    • A significant increase in schizophrenia symptoms, as determined by a healthcare professional’s rating scale
    • Clinically significant, deliberate self-injury or violent behavior resulting in suicide, injury, or significant damage
    • Suicidal or homicidal ideation and aggressive behavior



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