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About INVEGA TRINZA® | Janssen Portfolio of Long-Acting Injections
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INVEGA TRINZA® (paliperidone palmitate) has the same medication for schizophrenia as INVEGA SUSTENNA®, but is given once every 3 months.

In making the transition to INVEGA TRINZA®, you can feel confident that the schizophrenia medication you need is being gradually released into your system every day for 3 months to help control symptoms. And long-acting injections (LAI) like INVEGA TRINZA® can help delay another episode so you can focus more on the goals, even long-term ones, that are important to you.

According to the 2020 American Psychiatric Association Practice Guideline, many patients may prefer the convenience of an infrequent injection rather than having to remember to take oral medication.

As with any medication, there are side effects to consider. But it’s important to be informed of all the treatment options available that could be a good fit for your life.

Real people,
real stories

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Patrick’s* first love is music. Being diagnosed with schizophrenia has not diminished his passion as he works towards his goal of establishing a music career.

Do these stories inspire you? Do you want to inspire others with your story?

Consider sharing your journey

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How to start treatment with

INVEGA TRINZA® is different from INVEGA SUSTENNA® and INVEGA HAFYERATM in that it’s an injection given every 3 months. Your healthcare professional will start treatment for your schizophrenia with INVEGA SUSTENNA®, the once-monthly version of the active medication in INVEGA TRINZA®. After being adequately treated for at least 4 months, you and your healthcare professional can together make the decision to transition to INVEGA TRINZA®. There are steps that your Treatment Team will take to help you transition:

  • Your healthcare professional will need to test for tolerability using the active medication. Then you will receive 2 weekly starting doses of INVEGA SUSTENNA®. If you are currently taking INVEGA SUSTENNA®, this test and these starting doses are not necessary
  • You will receive INVEGA SUSTENNA® for at least 4 months in a row into the muscle of your upper arm or buttocks
  • After you have been adequately treated with INVEGA SUSTENNA® for at least 4 months, you and your healthcare professional can discuss whether a transition to receiving INVEGA TRINZA® every 3 months is appropriate for you

It can be challenging, but it’s important to be patient when transitioning to INVEGA TRINZA® so you and your healthcare professional can find you the right dose that will help control schizophrenia symptoms with the fewest side effects. It’s very important that you go to all of your injection appointments. If you miss an injection, talk to your Treatment Team as soon as possible. If you are experiencing symptoms or side effects, be sure to let your healthcare professional know. You and your Treatment Team members can also discuss options to help remember your injection appointments, or if you might be able to receive your injection at a place near you other than your healthcare provider’s office.

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Proven effectiveness 
in delaying another 

In a long-term study that compared INVEGA TRINZA® to a placebo in adults living with schizophrenia, those taking INVEGA TRINZA® remained relapse-free for longer.

  • The results

    In a long-term study, 93% of patients taking INVEGA TRINZA® did not experience a significant return of schizophrenia symptoms vs 77% of those not treated

  • The study design

    After a 3-week screening period for medication tolerability, 506 people living with schizophrenia were all treated with 5 doses of INVEGA SUSTENNA® over 17 weeks. After that, patients whose symptoms were stable received 1 dose of INVEGA TRINZA® over 12 weeks. Then, participants were randomly assigned to receive either an injection of INVEGA TRINZA® every 3 months or a placebo injection every 3 months

  • What is considered an episode in the study?

    For purposes of the study, an episode is defined as one or more of the following:

    • Hospitalization for schizophrenia symptoms (involuntary or voluntary)
    • A significant increase in schizophrenia symptoms, as determined by a physician’s rating scale
    • Clinically significant, deliberate self-injury or violent behavior resulting in suicide, injury, or significant damage
    • Suicidal or homicidal ideation and aggressive behavior
  • The most common side effects of INVEGA TRINZA® include:
    • Injection site reactions
    • Weight gain
    • Headache
    • Upper respiratory tract infections
    • Feeling restlessness or difficulty sitting still
    • Slow movements
    • Tremors
    • Stiffness
    • Shuffling walk
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What to discuss with your doctor before starting INVEGA TRINZA®

It’s important that your Treatment Team knows everything about your medical history so that they can help find the best medication for you. Before starting INVEGA TRINZA®, you should talk to your healthcare professional, especially if you:

  • Think you might be allergic to paliperidone, paliperidone palmitate, risperidone, or any of the ingredients in INVEGA TRINZA®. See the Full Prescribing Information for a complete list of ingredients
  • Have had Neuroleptic Malignant Syndrome (NMS)
  • Have or have had heart problems, including a heart attack, heart failure, abnormal heart rhythm, or long QT syndrome
  • Have or have had low levels of potassium or magnesium in your blood
  • Have or have had uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia)
  • Have or have had kidney or liver problems
  • Have diabetes or have a family history of diabetes
  • Have had a low white blood cell count
  • Have had problems with dizziness or fainting or are being treated for high blood pressure
  • Have or have had seizures or epilepsy
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. It is not known if INVEGA TRINZA® will harm your unborn baby
    • If you become pregnant while taking INVEGA TRINZA®, talk to your healthcare professional about registering with the National Pregnancy Registry for Atypical Antipsychotics. You also can register by calling 1-866-961-2388.
    • Infants born to women who are treated with INVEGA TRINZA® may experience symptoms such as tremors, irritability, excessive sleepiness, eye twitching, muscle spasms, decreased appetite, difficulty breathing, or abnormal movement of arms and legs. Let your healthcare professional know if these symptoms occur.
  • Are breastfeeding or plan to breastfeed. INVEGA TRINZA® can pass into your breast milk. Talk to your healthcare professional about the best way to feed your baby if you receive INVEGA TRINZA®.

You should also tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medications, vitamins, and herbal supplements. It can be helpful to keep a list of your medicines to show to your healthcare professional or pharmacist when you get a new medication.

Patients (particularly the elderly) taking antipsychotics with certain health conditions or those on long-term therapy should be evaluated by their healthcare professional for the potential risk of falls.

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Treatment Change
Discussion Guide

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Know about side effects

Like any other medication, side effects can occur in some people. The most common side effects of INVEGA TRINZA® are:

  • Injection site reactions (during a clinical trial, 3% of those treated with INVEGA TRINZA® experienced some sort of reaction at the injection site vs 0% with placebo)
  • Weight gain
  • Headache
  • Upper respiratory infections
  • Feeling of restlessness or difficulty sitting still
  • Slow movements
  • Tremors
  • Stiffness
  • Shuffling walk

Please see Important Safety Information below for additional information.

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Janssen CarePath

Information you may need to help you get started and stay on track. Janssen CarePath is here to help answer your questions about treatment with INVEGA TRINZA®. Once you and your doctor have decided that INVEGA TRINZA® is right for you, we will help you find resources you may need to get started and stay on track. We will give you information on your insurance coverage, potential out-of-pocket costs, and treatment support, and identify options that may help make your treatment more affordable.

Medication is just one part of the journey. Working with his Treatment Team, Patrick* knows the difference that the right support can make.

*Patrick is on a schizophrenia treatment journey with INVEGA TRINZA®, given by injection from a healthcare professional. He began treatment after being adequately treated with INVEGA SUSTENNA® (paliperidone palmitate), the once-monthly version of the medication with the same ingredient, for at least 4 months.