The Janssen Portfolio of Long-Acting Injections
Featuring INVEGA SUSTENNA®, INVEGA TRINZA®, and the only 6-month schizophrenia injection, INVEGA HAFYERATM
The only portfolio that offers control of schizophrenia symptoms for 1, 3, or 6 months
Together, INVEGA SUSTENNA® (paliperidone palmitate), INVEGA TRINZA® (paliperidone palmitate), and newly approved INVEGA HAFYERATM (paliperidone palmitate) are part of the Janssen portfolio of long-acting injections (LAIs). They have the same active medication, but are designed to be gradually released into your system over different periods of time. That way, you can feel confident that the schizophrenia medication you need is in your system to help control symptoms for a month,* 3 months,† or 6 months‡ after a single dose.
INVEGA SUSTENNA®, INVEGA TRINZA®, and INVEGA HAFYERATM can help control schizophrenia symptoms and help delay another episode.
In a pivotal long-term study, 90% of patients taking INVEGA SUSTENNA® did not experience a significant return of schizophrenia symptoms vs 66% of those not treated.
In a separate pivotal long-term study, 93% of patients taking INVEGA TRINZA® did not experience a significant return of schizophrenia symptoms vs 77% of those not treated.
A long-term, global clinical study was conducted to show whether INVEGA HAFYERATM was as effective as INVEGA TRINZA® in symptom control with similar safety and side effects. In this study, 92.5% of patients treated with INVEGA HAFYERATM and 95% of patients treated with INVEGA TRINZA® did not experience an episode at 12 months.
As with any medicine, INVEGA SUSTENNA®, INVEGA TRINZA®, and INVEGA HAFYERATM may cause side effects in some people, so the risks are important to consider as you and your healthcare professional make decisions about your treatment.
Speak with your healthcare professional, and please see Important Safety Information below or see the full Prescribing Information, including Boxed WARNING, by clicking the Expand button below.
*After receiving 2 starting doses when treating with INVEGA SUSTENNA®.
† When treating with INVEGA TRINZA® after being adequately treated with INVEGA SUSTENNA® for at least 4 months.
‡ When treating with INVEGA HAFYERATM after being adequately treated for at least 4 months or INVEGA TRINZA® for one 3-month cycle.
How “gradual release”
What makes long-acting injections different from a daily pill is that the medication is designed to be slowly released into your system over a specific period of time. For example, the active medication in a daily pill may be released over 24 hours, so you have to take it every day. But the active medication in INVEGA SUSTENNA® is gradually released over a month after 2 initiation doses. According to the 2020 American Psychiatric Association Practice Guideline, with LAIs “there is greater assurance that a patient will receive medication continuously because there are fewer opportunities to miss a medication dose…” And since your Treatment Team will be the ones giving you your injection, they will be aware immediately if you miss a dose.
After being adequately treated for at least 4 months, for certain adult patients diagnosed with schizophrenia, you and your healthcare professional can make the decision to transition to INVEGA TRINZA® or INVEGA HAFYERATM. After your healthcare professional gives you your injection of INVEGA TRINZA®, the medication will be gradually released into your system over 3 months. After your healthcare professional gives you your injection of INVEGA HAFYERATM, the medication will be gradually released into your system over 6 months.
With a continuous amount of medication in your system, you can feel more in control of schizophrenia symptoms and help delay another episode.
The choice to move from once-monthly treatment to 3-month or 6-month treatment
The decision to transition from treating your schizophrenia with 1 dose a month with INVEGA SUSTENNA® to once every 3 months with INVEGA TRINZA® or once every 6 months with INVEGA HAFYERATM is one that you and your healthcare professional can make together. It’s different for everyone, based on what works best for you, so what is right for one person may not be what’s right for you.
What’s important to remember is that you’re the most important member of your treatment team. Be sure to speak up and stay informed about which treatment options you feel can best help you control your schizophrenia symptoms so you can move forward and focus on your goals.
Ways to stay successful
on LAI treatments
- Be involved with and informed about your treatment plan. Your opinions are valuable, and it is important that you have a say when it comes to working with your Treatment Team
- Plan for your injection appointments. Know how you are getting to your appointment, have important numbers handy in case you’re running late or need to reschedule, and bring a journal of your symptoms to share with your Treatment Team
- Find a convenient injection location. There might be an opportunity for you to receive your injection somewhere other than your doctor’s office, so be sure to talk with your team about finding additional injection locations near you
- Keep your appointments. Staying on schedule with receiving injections helps keep symptoms controlled, so tell your healthcare professional immediately if you miss a dose
- Keep your Treatment Team informed. They can help you manage side effects by changing your medication, adjusting your dosage, or by adding other medications to help make side effects more manageable
- Follow the rest of your treatment plan. Remember that medication is just one part of your journey
Elizabeth* was diagnosed with schizophrenia at 25, and didn’t tell anyone about her symptoms. After being in and out of the hospital, she decided to make a change in her treatment.
* Elizabeth is a volunteer with the SHARE Network, a volunteer program dedicated to helping adults living with schizophrenia share their personal health stories.